Jouni Uitto Selected Research

Arterial calcification of infancy

1/2022	Oral supplementation of inorganic pyrophosphate in pseudoxanthoma elasticum.
1/2022	ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification.
1/2019	Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI.
1/2019	Pseudoxanthoma Elasticum as a Paradigm of Heritable Ectopic Mineralization Disorders: Pathomechanisms and Treatment Development.
1/2019	Adenovirus-Mediated ABCC6 Gene Therapy for Heritable Ectopic Mineralization Disorders.
7/2018	Etidronate prevents, but does not reverse, ectopic mineralization in a mouse model of pseudoxanthoma elasticum (Abcc6-/- ).
6/2017	Elevated dietary magnesium during pregnancy and postnatal life prevents ectopic mineralization in Enpp1asj mice, a model for generalized arterial calcification of infancy.
12/2016	Variable patterns of ectopic mineralization in Enpp1asj-2J mice, a model for generalized arterial calcification of infancy.
1/2016	Dual Effects of Bisphosphonates on Ectopic Skin and Vascular Soft Tissue Mineralization versus Bone Microarchitecture in a Mouse Model of Generalized Arterial Calcification of Infancy.
1/2015	The effects of bisphosphonates on ectopic soft tissue mineralization caused by mutations in the ABCC6 gene.

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Jouni Uitto Research Topics

Disease

30	Pseudoxanthoma Elasticum (Gronblad Strandberg Syndrome) 01/2022 - 08/2005
24	Epidermolysis Bullosa Dystrophica (Dystrophic Epidermolysis Bullosa) 01/2022 - 01/2005
20	Epidermolysis Bullosa 01/2022 - 04/2002
14	Skin Diseases (Skin Disease) 12/2021 - 07/2008
12	Arterial calcification of infancy 01/2022 - 07/2013
10	Wounds and Injuries (Trauma) 01/2022 - 03/2006
9	Bullous Pemphigoid (Pemphigoid) 01/2022 - 10/2002
7	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 10/2021 - 01/2002
7	Ichthyosis (Xeroderma) 11/2020 - 04/2003
6	Neoplasms (Cancer) 06/2021 - 04/2002
5	Calcinosis 01/2022 - 10/2006
5	Keloid 01/2021 - 01/2007
5	Blister (Bulla) 11/2017 - 05/2003
4	Epidermolysis Bullosa Simplex (Epidermolysis Bullosa Herpetiformis Dowling Meara) 01/2018 - 04/2003
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2010 - 04/2002
4	Muscular Dystrophies (Muscular Dystrophy) 02/2005 - 06/2002
3	Cicatrix (Scar) 01/2022 - 01/2009
3	Vitiligo 12/2020 - 01/2017
3	Inflammation (Inflammations) 02/2015 - 03/2011
3	Stroke (Strokes) 12/2013 - 01/2012
3	Epidermolysis bullosa with pyloric atresia 01/2010 - 06/2003
3	Pemphigus (Pemphigus Vulgaris) 04/2003 - 01/2002
2	Ankylosis 01/2022 - 06/2007
2	Vascular Calcification 01/2021 - 04/2013
2	Keratitis, Ichthyosis, and Deafness (KID) Syndrome 11/2020 - 05/2012
2	Autoimmune Diseases (Autoimmune Disease) 08/2020 - 05/2003
2	Autosomal Recessive Epidermolysis Bullosa Simplex 10/2019 - 06/2002
2	Pain (Aches) 01/2019 - 06/2008
2	Hypotrichosis 12/2017 - 04/2003
2	Myocardial Infarction 12/2013 - 06/2012
2	Blindness (Hysterical Blindness) 12/2013 - 06/2012
2	Cardiovascular Diseases (Cardiovascular Disease) 06/2012 - 01/2012
2	Infections 06/2008 - 10/2006
2	Neoplasm Metastasis (Metastasis) 03/2007 - 03/2002
2	Epidermolysa bullosa simplex and limb girdle muscular dystrophy 04/2004 - 06/2002
1	Hereditary Sensory and Autonomic Neuropathies (HSAN) 01/2022
1	Acantholysis 01/2022
1	Segmental Darier Disease 01/2022
1	Warts (Wart) 01/2022
1	Darier Disease (Darier's Disease) 01/2022
1	Acanthoma 01/2022

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2002
21	Collagen Type VIIIBA 11/2021 - 05/2003
15	AntigensIBA 01/2022 - 01/2002
11	CollagenIBA 01/2022 - 04/2004
9	diphosphoric acid (pyrophosphoric acid)IBA 01/2022 - 01/2016
6	PlectinIBA 01/2010 - 06/2002
5	MagnesiumIBA 06/2017 - 06/2009
4	AutoantibodiesIBA 01/2010 - 12/2002
4	KalininIBA 06/2008 - 01/2002
4	Laminin (Merosin)IBA 02/2006 - 05/2003
3	Protein Isoforms (Isoforms)IBA 01/2022 - 04/2002
3	Durapatite (Hydroxylapatite)IBA 01/2022 - 12/2018
3	Nonsense Codon (Nonsense Mutation)IBA 06/2021 - 12/2013
3	Keratin-5 (Keratin 5)IBA 10/2019 - 04/2003
3	Alkaline PhosphataseIBA 01/2019 - 06/2007
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 06/2003
3	Etidronic Acid (HEDP)FDA LinkGeneric 07/2018 - 01/2015
3	CytokinesIBA 11/2017 - 01/2012
3	ChemokinesIBA 11/2017 - 01/2016
3	MineralsIBA 01/2015 - 02/2011
3	calcium phosphateIBA 12/2013 - 06/2012
3	Vitamin K FDA Link 04/2013 - 02/2009
3	Matrix Gla ProteinIBA 04/2013 - 06/2007
3	NucleotidesIBA 01/2005 - 04/2003
2	EnzymesIBA 01/2022 - 12/2020
2	Adenosine Triphosphate (ATP)IBA 01/2022 - 12/2016
2	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
2	Interferon-gamma (Interferon, gamma)IBA 01/2022 - 04/2006
2	Losartan (Cozaar)FDA LinkGeneric 01/2022 - 01/2021
2	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2012
2	Connexin 26IBA 11/2020 - 05/2012
2	LipidsIBA 06/2020 - 11/2011
2	Amino Acids FDA Link 12/2017 - 04/2003
2	LigandsIBA 11/2017 - 01/2016
2	Biological ProductsIBA 01/2016 - 04/2002
2	Diphosphonates (Bisphosphonates)IBA 01/2016 - 01/2015
2	Proteoglycans (Proteoglycan)IBA 12/2013 - 06/2012
2	Messenger RNA (mRNA)IBA 06/2012 - 01/2009
2	ConnexinsIBA 05/2012 - 04/2003
2	NF-kappa B (NF-kB)IBA 01/2012 - 02/2006
2	alpha-2-HS-GlycoproteinIBA 05/2010 - 06/2007
2	Integrin alpha6beta4IBA 01/2010 - 01/2005
2	Phosphates (Orthophosphate)IBA 12/2009 - 01/2009
2	LuciferasesIBA 07/2008 - 02/2003
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2008 - 06/2008
2	CalciumIBA 06/2008 - 04/2002
2	Peptides (Polypeptides)IBA 01/2005 - 10/2003
2	Immunoglobulin G (IgG)IBA 06/2004 - 05/2003
2	Immunoglobulin A (IgA)IBA 06/2004 - 05/2003
1	Antiviral Agents (Antivirals)IBA 01/2022
1	ectonucleotide pyrophosphatase phosphodiesterase 1IBA 01/2022
1	NexusIBA 01/2022
1	Lamin Type A (Lamin A)IBA 01/2022
1	PyrinIBA 12/2021

Therapy/Procedure

25	Therapeutics 01/2022 - 12/2004
3	Precision Medicine 12/2018 - 01/2017
2	Transplantation 01/2016 - 09/2015
1	Aftercare (After-Treatment) 01/2022
1	Oral Administration 01/2022